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CBD and THC in combination with drugs and other substances

Currently, many patients with health problems have access to cannabis products because medications prescribed by a doctor are not enough to provide relief. According to previous studies, no adverse side effects were observed, as patients generally tolerate CBD well. It is known, however, that CBD and THC reduce the effect of some drugs, such as, for example, antidepressants, by strengthening or relieving them. Therefore, it is worth learning more about the possible interactions of CBD and THC with other drugs.

If you want to learn more about the possible side effects of CBD oil, we recommend this article on our blog.

In most cases, the reasons for the interaction of cannabis products with drugs and other substances are known. Often this happens because these substances have similar mechanisms of action as antidepressants.

Mutual influence

CBD and THC may increase or decrease the effect of some drugs. But the opposite may also happen, as some CBD and THC effects may be exacerbated or impaired by the use of certain drugs. In both cases, there is the possibility of interaction, which means that certain effects increase and others decrease.

Main interactions with the following drugs:

Antidepressants (selective serotonin reuptake inhibitors): THC may increase the effect of fluoxetine.

Antidepressants (tricyclic): calming, hypotensive and increasing the rhythm of the heart, the effect of amitriptyline may be exacerbated by the use of THC.

Benzodiazepines (in sedatives such as Valium®): CBD and THC may affect the effects of these drugs.

Beta blockers: they are used to treat high blood pressure and heart problems because they inhibit the action of some hormones (epinephrine, norepinephrine). They reduce the increase in heart rate caused by THC.

Drugs for glaucoma: Glaucoma, also known as a green star, damages nerve cells, which in the worst case can lead to blindness. The effects of marijuana and medications that lower the intraocular pressure may occur at the same time, reinforcing each other. In rare cases, a small increase in intraocular pressure may occur by taking CBD.

Drugs that suppress nausea: There are two main groups of drugs that suppress nausea and nausea and are often used in cancer patients undergoing chemotherapy: phenothiazines and antagonists or serotonin triptans. The effect of such drugs can be increased by THC because phenothiazines reduce the psychotropic effects of THC.

Opiates: The calming effect and pain relief attributed to both marijuana and opiates can strengthen each other. In addition, CBD may counteract nausea caused by opiates.

Not recommended combinations

Alcohol: while consuming THC and alcohol, some effects may be increased. For example, a calming and sleep-inducing effect can affect road safety.

Substances that increase the heart rate: The effects of THC and the effects of increasing the heart rate of substances such as amphetamine, adrenaline, atropine, and cocaine may turn out to be very detrimental to health if supplemented.


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Helpful tips on how to use cannabis in combination with other drugs

If you want to use cannabis products to relieve pain in combination with other analgesics, it is advisable to use cannabis extremely slowly and carefully without the usual medication. Different patients react differently and therefore you never know exactly how your body reacts to certain substances. If you notice symptoms go away while using cannabis products, try reducing the opiate doses, in consultation with your doctor.

Some patients have completely stopped using opiates within a few months, while in others, only a weak effect was noticed.

The same applies to drugs that are used to relax the muscle, for example in multiple sclerosis or paraplegia. The therapy can be supplemented with cannabis products, but only with the consent of the doctor.

Circulatory changes through cannabis use can be felt in two ways, either as a rapid pulse or dizziness. If you also use cannabis products in addition to medicines that may affect your circulation, be careful and slow to avoid putting too much pressure on the circulation.


Numerous studies have shown that CBD may positively affect the effects of many drugs, including antidepressants, therefore supplementation with natural products containing CBD and THC in consultation with the treating physician would be useful in the following cases:

• to relieve pain

• to stop nausea

• for muscle relaxation

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